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Jan 23, 2021 · Sitagliptin phosphate monohydrate is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco2 cell extracts. Sitagliptin phosphate exhibits a potent inhibitory effect on DPP4 with IC50 of 19 nM from Caco2 cell extracts [1]. Sitagliptin reduces in vitro migration of isolated splenic CD4 Tcells through a pathway involving cAMP/PKA/Rac1 ...

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December 2013 – Page 2 – All About Drugs

Step 3. Preparation: A solution of 592 g (2 mol) of BPI02 and 600 mL of acetic acid in a 5 L reaction flask was cooled to 0°C; 1640 mL ( mol) of concentrated nitric acid was slowly added. The internal temperature should not exceed 10 °C. While cooled below 0°C, 1 L .

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